Chunshan gui and oatp1b1

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August undefined, 2024

WebJun 30, 2011 · At present, Chunshan Gui et al. have confirmed that ursolic acid was the selective OATP1B3 and OATP1B1 inhibitor (Chunshan et al. 2010). Therefore, the drug … WebChunshan Gui Organic anion transporting polypeptide 1B1 (OATP1B1) is a key hepatic uptake transporter whose inhibition could lead to adverse drug-drug and drug-food interactions.

Inhibition of OATP1B1-mediated estradiol-17β

WebJun 30, 2011 · Chunshan Gui et al. have confirmed that ursolic acid is a selective OATP1B3 and OATP1B1 inhibitor (Chunshan et al. 2010 ). Therefore, there may be an interaction between ursolic acid and rosuvastatin. A reasonable combination use of rosuvastatin and herbal medicines containing ursolic acid has important clinical value. WebChunshan Gui, a Brett Wahlgren, a Gerald H. Lushington, b and Bruno Hagenbuch a, c, * ... Inhibition of OATP1B1-mediated estradiol-17β-glucuronide uptake by 37 nuclear … mark and spencer online philippines

(PDF) Human Organic Anion Transporting Polypeptides 1B1

WebDec 24, 2024 · Taken together with our previous results 7 that the mutations of OATP1B1*5, *15 and CYP2C9*2, *3 significantly affect the transport and metabolism of glimepiride and gliclazide, it can be deduced ... WebMar 1, 2010 · Comparison of OATP1B1- and OATP1B3-mediated transport of fluorescent substrates. Uptake was measured with 1 µM of the indicated fluorescent compounds on 24-well plates for 30 min. Values are means ± SE of two combined independent experiments each performed with triplicate determinations. WebIdentification, Kidetermination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17β-glucuronide transport Chunshan Guia, Brett Wahlgrena, Gerald H. Lushingtonb, and Bruno Hagenbucha,c,* mark and spencer online shopping ireland

Gly45 and Phe555 in Transmembrane Domains 1 and 10 …

Cloning/Characterization of the Canine Organic Anion …

WebWe have used OATP1B1- or OATP1B3-expressing Chinese Hamster Ovary cells on 96-well plates and determined uptake of fluorescein-methotrexate (FMTX). We validated the assay with known inhibitors and screened the well characterized Prestwick library of 1120 drugs. WebAug 6, 2024 · A number of drug-drug and drug-food interactions have been associated with OATP1B1 and 1B3, affecting the pharmacokinetics and pharmacodynamics of their … nausea cured by eatingWebMay 29, 2014 · Chunshan Gui Authors' Affiliations: ... Transport of paclitaxel, docetaxel, and cabazitaxel was studied in vitro using various cell lines transfected with OATP1B1, OATP1B3, or the rodent equivalent OATP1B2. Pharmacokinetic studies were done in wild-type and OATP1B2-knockout mice in the presence or absence of polysorbate 80 (PS80) … nausea day after colonoscopy

"WebChunshan Gui Brett Wahlgren Gerald Lushington Bruno Hagenbuch Evidence shows that drug-drug interactions can occur at the level of drug transporters such as the organic anion transporting... " - Chunshan gui and oatp1b1

Chunshan gui and oatp1b1

Development of a cell-based high-throughput assay to screen for ...

WebMar 1, 2024 · OATP1B1 has broad substrate specificity and the structures of its substrates/inhibitors are quite diverse (Hagenbuch and Gui, 2008). With the increasing number of structurally diverse substrates/inhibitors for OATP1B1, it’s almost impossible to reliably superimpose hundreds of these molecules to carry out 3D-QSAR analysis. WebAug 9, 2008 · Europe PMC is an archive of life sciences journal literature. Search life-sciences literature (Over 39 million articles, preprints and more)

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WebNov 1, 2009 · Search worldwide, life-sciences literature Search. Advanced Search WebChunshan Gui Brett Wahlgren Gerald Lushington Bruno Hagenbuch Evidence shows that drug-drug interactions can occur at the level of drug transporters such as the organic anion transporting...

WebChunshan Gui1 and Bruno Hagenbuch1,2* 1Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 ... OATP1B1. Gui and Hagenbuch PROTEIN SCIENCE VOL 18:2298—2306 2299. sulfate transport from 70% (chimera T7-12) to 32% (chimera T9-12) and 3% (chimera T11-12). … WebOATP1B1, OATP1B3, and OATP2B1 signiﬁcantly trans-ported PSP with their transport activities 2-fold greater than that of empty vector control, while human NTCP, OCT1, and …

WebDec 24, 2024 · Taken together with our previous results 7 that the mutations of OATP1B1*5, *15 and CYP2C9*2, *3 significantly affect the transport and metabolism of glimepiride … WebApr 1, 2010 · Author links open overlay panel Chunshan Gui a, Bruno Hagenbuch a b. Show more. Add to Mendeley. Share. Cite. ... (Hagenbuch and Gui, 2008, König et al., 2006). Mice and rats have only a single transporter in the OATP1B family that is the ortholog of human OATP1B1 and OATP1B3 which arose through gene duplication after …

WebJan 1, 2024 · Chunshan Gui Organic anion transporting polypeptide 1B1 (OATP1B1) is a key hepatic uptake transporter whose inhibition could lead to adverse drug-drug and drug-food interactions.

WebSep 16, 2009 · The liver-specific organic anion transporting polypeptides OATP1B1 and OATP1B3 are highly homologous and share numerous substrates. However, at low concentrations OATP1B1 shows substrate selectivity for estrone-3-sulfate. mark and spencer outlet onlineWebIdentification, Ki determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17β-glucuronide transport … mark and spencer romaniaWebThis type of analysis has been previously successfully used to determine the type of interaction of OATP1B1 with a wide range of physiological substrates and fibrates (Gui et al., 2009; Yamazaki ... nausea day after surgeryWebAug 6, 2024 · A number of drug-drug and drug-food interactions have been associated with OATP1B1 and 1B3, affecting the pharmacokinetics and pharmacodynamics of their substrate drugs. 8–16 It has also been reported that many natural substances present in food or dietary supplements such as flavonoids could intact with OATP1B1 and 1B3 and … mark and spencer philippines foodWebDec 16, 2024 · OATP1B1, OATP1B3, and OATP2B1, with OATP1B3 showing the highest transport eﬃciency. The Kmvalues for OATP1B1-, OATP1B3-, and OATP2B1-mediated PSP uptake were 11.3 ± 1.5, 7.0 ±1.5, and 5.1 ±1.0... mark and spencer philippinesWebAug 9, 2008 · Human organic anion transporting polypeptides (OATP) 1B1 and 1B3 are multispecific transporters that mediate uptake of amphipathic organic compounds into hepatocytes. The two OATPs contain 12 transmembrane domains (TMs) and share 80% amino acid sequence identity. mark and spencers bankWebJianqing Ruan, and Chunshan Gui* Cite This: ACS Omega 2024, 6, 35844−35851 Read Online ... (OATP1B1), OATP1B3, OATP2B1, Na+/taurocholate cotransporting polypeptide (NTCP), organic cation transporter 1 (OCT1), and OAT2, have been investigated to see whether they are involved in the hepatic uptake of PSP. An in vitro cell-based study ... nausea day before period is due