WebKlotho is an anti-aging protein with pleiotropic actions that exerts organ protection. Several lines of evidence support the notion that Klotho functions as a human aging-suppression … WebNov 22, 2024 · This violin plot shows concentrations of Klotho in CSF measured by commercially available human soluble α-Klotho assay enzyme-linked immunosorbent assy kit in different clinical groups. AD indicates Alzheimer disease; AD-MCI, AD with mild cognitive impairment; and CN, cognitively healthy controls. Figure 2.
Klotho Protein as the Key to Lion
WebJun 14, 2024 · The klotho (KL) family of genes includes α-klotho, β-klotho and γ-klotho [], which are all translated as single-pass transmembrane proteins. α-klotho is highly expressed in the brain and kidney, and to a lesser extent in other organs [].In the periphery, transmembrane α-klotho acts as a co-receptor for FGF23 to increase binding affinity to … WebOther studies have suggested that Klotho overexpression may have a protective effect on nerves and reduce nerve sensitivity. For example, a study published in the Journal of Neuroinflammation in 2024 showed that Klotho overexpression reduced neuropathic pain in rats by reducing inflammation and oxidative stress in the spinal cord. While these ... finalshell for mac 下载
Suppression of aging in mice by the hormone Klotho - PubMed
WebKlotho levels are associated with insulin production in human and animal studies. The Centers for Disease Control indicate that >29 million Americans are living with diabetes, … WebMay 30, 2024 · Klotho deficiency resulted in a marked increase in beclin 1 co-immunoprecipitation with BCL2 in the kidney (Fig. 4a, b), in support of the concept that disruption of beclin 1 and BCL2 binding may ... WebApr 30, 2024 · Klotho, known as an anti-aging protein, has been reported to be predominantly synthesized in the human brain and kidneys, although it is expressed in multiple organs [ 32, 33, 34 ]. In the kidneys, it is known to be expressed mainly in the proximal and distal tubules. finalshell for mac