WebSep 1, 2012 · Abstract. The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation in higher eukaryotes and is a critical downstream target of the tumor suppressor pRB. The pRB/E2F pathway is defective in most human tumors, resulting in deregulated E2F activity that induces uncontrolled cell proliferation, a hallmark of tumor … WebSep 3, 2024 · Deactivation of RBM38 could disrupt p53-mdm2 loop function and promote HCC, but its role and molecular mechanism remain scanty and contradictory. In the …
Role and mechanism of RBM38 in inhibiting BCa cell …
WebAug 20, 2024 · It has been shown in multiple experimental and biological investigations that kaempferol, an edible flavonoid generated from plants, may be used as an anti-cancer drug and has been shown to have anti-cancer properties. Many signaling pathways are altered in cancer cells, resulting in cell growth inhibition and death in various tumor types. Cancer is … WebApr 12, 2024 · Fig. 1: USP1 is an important regulator of Hippo signaling activity, and its expression is elevated in human hepatocellular carcinoma. A The flowchart shows the siRNA screening procedure for ... grandmother\u0027s rocking chair
RBM38 is negatively regulated by miR‑320b and enhances …
WebMar 9, 2024 · Results report that RBM38 mediates direct inhibition of c-Myc expression, which in turn suppresses RBM38 expression. Thus, it can be concluded that RBM38 and c … WebThis reduction was shown to require the N- and C-terminal regions of Rbm38, along with an important role being played by the RNA-recognition motif of Rbm38. ... Cancer Res. 2014, … WebMar 15, 2024 · Cancer cells are known to adapt a few alternate pathways to maintain cellular iron balance. In NSCLS (non-small cell lung carcinoma cells) EGFR, growth factor that regulates growth, survival, proliferation and differentiation in mammalian cells has been demonstrated to affect iron metabolism by directly binding and redistributing TfR-1 [41,44]. grandmother\u0027s rings with birthstones